I start with a thumbnail for composition, then I refine that in red a little before I print. I then ink the panel; with quill generally, (I love quills), and scan it back into Photoshop. I tend to prefer paper for inking as apposed to my cintiq because I can't zoom, and I otherwise have no self control. Once I get the panel scanned you simply increase the value of Reds in Hue and Saturation in PS, and you've got clean linework. I also use a handy little filter from Flaming Pear, called Ghost - that takes out the white, and my linework is then truly isolated. I paint under that layer, usually in grey, and I adjust the hues with adjustment layers. In this case I'd also color the line to match whatever hue that was...add finishing touches like pupils and shine here and there....(eyes are finicky, so zoom is good) and viola. A panel.
Thanks for reading! Hope you're enjoying the story so far.